Ningguo GuoAnBang Pharma Industry Co., Ltd.

Product Name: Estazolam Tablets

Types of drugs: prescription drugs, Western Medicine

Product advantages: Basic Medicine, class a medical insurance, new rural cooperative medical system

Approval number: national medicine quasi word H34022967

[product specification]: 1mg * 100 / plastic bottle, 1mg * 150 / aluminum bubble box

[usage and dosage] adults should be calm once a day, 1~2mg, 3 times a day. Hypnosis, 1~2mg, bedtime clothes. Antiepileptic, anticonvulsant, once a 2~4mg, 3 times a day.

[product efficacy]: mainly used for anti anxiety, insomnia. Also used for stress, fear, and anticonvulsant and anticonvulsant.

[ingredients] this product is the main ingredients of estazolam

[character] this product is white.

[pharmacological effect] this product is benzene two nitrogen Zhuo kind of anti anxiety medicine. Can cause different parts of the central nervous system inhibition, with the increase in dosage, clinical manifestations from mild sedation to hypnosis, or even coma. 1. has the function of anti anxiety, sedation and hypnosis. It acts on the two receptors of benzene, strengthens the function of GABA receptor in the central nervous system, and affects the function of limbic system. It can obviously shorten or cancel the fourth phase of NREM sleep, block the activation of reticular formation, and have sedative hypnotic effect on human. 2. anticonvulsant effect: it can inhibit the abnormal discharge of epileptic foci in the central nervous system, but it can not prevent the abnormal discharge. 3. skeletal muscle relaxation: small doses can inhibit or reduce the facilitation of reticular formation to spinal motor neurons, and larger doses can promote presynaptic inhibition in spinal cord and inhibit multi synaptic reflex. 4. forgetting effects: the therapeutic dose may interfere with the establishment of memory pathways, and transient effects on near memory. 5. may pass through the placenta and secrete into the milk. 6. have addiction, a small number of patients can cause allergies.

[pharmacokinetics] oral absorption was rapid, and the plasma concentration reached peak value after 3 hours of oral administration. The concentration of serum was steady at 2~3 days. T1/2 was 10~24 hours and the binding rate of plasma protein was about 93%. Through the liver metabolism, through the kidney excretion, excretion slower.

[drug interaction] 1. combined with central depressant can increase respiratory depression. 2., addiction increases the risk of addiction when used in combination with other addictive drugs. 3., with wine and general anesthetics, clonidine, analgesics, phenothiazine, monoamine oxidase, A inhibitors and tricyclic antidepressants, can be synergistic with each other, should adjust the dosage. 4., combined with antihypertensive drugs and diuretic antihypertensive drugs, can increase the role of blood pressure. 5., the combination of F Naylor and cimetidine drug clearance slowed, plasma half-life. 6., with the use of paracetamol, because the latter slows down the metabolism, the need to adjust the amount of paracetamol. 7., when combined with levodopa, can reduce the efficacy of the latter. 8., combined with rifampin, increase the elimination of this product, lower blood concentration. 9. isoniazid inhibits the elimination of this product, resulting in increased serum concentration. 10. combined with digoxin can increase digoxin blood concentration and cause poisoning.

[adverse reactions] 1. common adverse reactions: dry mouth, lethargy, dizziness, fatigue, etc., large doses may have ataxia, tremor. 2. rare rash, leukopenia, 3. individual patients were excited, multilingual, sleep disorders, and even hallucinations. After stopping the drug, the symptoms soon disappear, 4. are dependent, but less severe. After a long period of use, withdrawal may result in withdrawal symptoms, which show agitation or depression.

[contraindications] caution: 1. acute alcoholic intoxication of the central nervous system in a state of suppression. 2. impairment of liver and kidney function. 3. myasthenia gravis. 4. acute or prone to angle closure glaucoma. 5. severe chronic obstructive pulmonary disease.

[precautions] 1, should not drink alcohol during the period of medication. 2, for other benzene two nitrogen Zhuo drug allergy, may be allergic to the drug. 3, liver and kidney function impairment, can extend the drug to eliminate half-life. 4, sudden withdrawal of epilepsy can lead to seizures. 5, severe mental depression can aggravate the condition, and even suicidal tendencies, preventive measures should be taken. 6, avoid long-term heavy use and addiction, such as long-term use should gradually reduce, not easy to stop suddenly. 7, respiratory depression or hypotension often suggest excessive. 8, the drug tolerance of small patients, the initial dosage is easy, and gradually increase the dose.

[drugs for pregnant women and lactating women] in three months of pregnancy, this medicine has increased the risk of fetal teratogenicity. Long term use of pregnant women can be addictive, so that the neonatal symptoms of withdrawal, late pregnancy medication affect neonatal central nervous activity. Medication before delivery and delivery can lead to weak neonatal muscle tension and should be used with caution. Lactating women should be used with caution.

[children medication] children under 18 years of age, the dosage has not been determined.

[older patients] the elderly are more sensitive to the drug, and start using small doses when they are resistant to anxiety. Pay attention to the dosage adjustment.

Excessive overdose can cause persistent mental disorders, lethargy, deep tremors, persistent silent speech, unstable standing, bradycardia, shortness of breath, or severe weakness. Excessive or poisoning should be treated as early as possible, including emetic or gastric lavage and respiratory support therapy of circulatory system. If you are excited, you should not use barbiturates. Flumazenil, a two receptor antagonist of benzene, can be used for the rescue and diagnosis of overdose of such drugs.